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Testopel is a brand name for testosterone pellets, which have also been approved for testosterone replacement therapy(TRT) in men. According to a study in the journal JAMA, the FDA approved testosterone pellets because of its low cost, low risk of side effects, and low cost of administration. But, the study found that only about 5.4 percent of the men receiving pellets received what the FDA called consistent, high and reliable treatment. Nearly all of them also experienced serious side effects ranging from dryness and weight loss to heart problems, depression and suicidal thoughts. The study found that the median age at testosterone treatments was 26, including 21 percent of men who were 30 years old or older. However, a majority of men who received pellets got testosterone only after they met a medical evaluation in which they met criteria for at least three medical disorders, the study said. Nearly half of the men in the study had heart disease, depression or other psychiatric problems. "As we try to do more to prevent these side effects, we also have to find better ways to address them," said Timothy Caulfield, the study's senior author and a clinical professor of medicine at the Harvard Medical School. The drug company that made Trenbolone HCl for TRT, Endo Pharmaceuticals, withdrew the product before it could go on the market. The drug, also known as levonorgestrel, is used for female hormone replacement treatment. It does not affect fertility. "This study is the first to document many of the potential issues in the management of men with testosterone therapy," said Joseph Bierman, chief scientific officer for Endo Pharmaceuticals, told Reuters Health. "Our primary job is to get this right." "The most important finding of the study is that most of the men were having serious side effects and there were still patients with serious side effects when this product was marketed," Bierman added. According to the CDC's National Center for Health Statistics, approximately 1.6 million American men in 2010 had been treated for prostate cancer, about a third with hormone treatments. Among men who receive treatment, the median age at death has been rising sharply recently, including a 7 percent increase from 1986 to 1986, and 1.4 percent increase from 2006 to 2010. According to Bierman, many doctors will consider TRT, but are afraid that patients will not accept higher doses because of side effects. The FDA has also been trying to reduce side effects by increasing side effects reporting through the National Cancer Institute to help physicians better understand Similar articles: